Caroline Amelie was born to Duke Christian August II and his wife, Countess Lovisa-Sophie Danneskjold-Samsøe. In 1856 she married the Duke of Middleton in a lavish ceremony in Copenhagen. She would have three kids with him, Pieter (the future king), Prince Eugen (1862) and Princess Liese (1864). However, their marriage was not happy and they were often separated. When her husband was deposed and exiled in 1881 the queen decided to stay in Brunant and not with him. Caroline lived out her days in Koningstad and she died in 1901.